ARA-290
The neuroprotective peptide — an 11-amino-acid fragment derived from erythropoietin (EPO) that targets tissue repair and chronic inflammation without EPO's blood-forming effects.
What is ARA-290?
ARA-290 (also called cibinetide) is a small peptide derived from a specific region of the EPO molecule.
It targets the innate repair receptor (IRR) — a receptor activated only when tissue is stressed or injured. That means ARA-290 can help with nerve repair, inflammation, and tissue healing in damaged areas without affecting red blood cell production the way full-length EPO would. It's been studied extensively for small-fiber neuropathy, sarcoidosis, and diabetic nerve pain.
What ARA-290 does
The main mechanisms and effects patients can expect from a well-run protocol.
Neuroprotection
- Supports small-fiber nerve repair
- Activates the innate repair receptor
- Helps with nerve sensitivity and pain
Anti-Inflammatory
- Reduces chronic low-grade inflammation
- Helpful in neuroinflammatory conditions
- Supports tissue healing in injured areas
Metabolic Support
- Studied for diabetic neuropathy
- Supports peripheral nerve function
- May help insulin-related symptoms
Recovery
- Patients report reduced nerve pain
- Better sleep when pain decreases
- Supports functional quality of life
Is this right for you?
ARA-290 tends to be a strong fit for patients dealing with the following.
- Patients with small-fiber neuropathy or nerve pain
- Those with chronic inflammation-driven symptoms
- Patients recovering from injury-related nerve issues
- Patients with diabetic neuropathy (with provider oversight)
How to use ARA-290
Your provider has prescribed a protocol tailored to your goals. Here are the key details to keep in mind.
Injection Frequency
Once daily subcutaneous injection, or as directed by your provider.
Injection Site
Subcutaneous into the abdomen. Rotate sites daily.
Duration
Typically run in structured cycles with a break between. Your provider will set the cadence based on your goals.
Storage
Keep refrigerated. Do not freeze. Let the vial warm slightly before injection.
What to expect
Everyone responds differently, but here's what patients typically experience.
Week 1
Early signs — some patients notice nerve symptoms softening slightly. Most don't feel dramatic changes yet.
Week 2-3
Nerve pain and burning sensations often begin to reduce. Sleep frequently improves when pain decreases.
Week 4+
Cumulative repair effects. Patients typically report the biggest quality-of-life changes after several weeks of consistent use.
Side effects
ARA-290 is generally well tolerated. Contact your provider if you experience anything unusual.
- Generally very well tolerated
- Mild injection-site redness
- Occasional mild fatigue early in protocol
- Unlike EPO, does not affect red blood cell production
Common questions
Is this the same as EPO?
No. ARA-290 is a fragment of EPO that keeps the repair-signaling effects but not the red-blood-cell effects. Different receptor, different job.
How long does it take to work?
Most patients need several weeks of consistent use before nerve pain and inflammation meaningfully reduce.
Can I stack it with BPC-157?
Yes — many patients combine ARA-290 with BPC-157 for broader repair coverage.
Our services
Based on your goals, your provider may recommend one or more of the following.
Testosterone, thyroid, and hormone balancing for men and women. Includes all medications, ongoing labs, provider check-ins, and one IV per month.
Physician-supervised GLP-1 medications (Semaglutide, Tirzepatide, Retatrutide) with labs and ongoing support.
Custom IV vitamin infusions including NAD+, high-dose Vitamin C, glutathione, methylene blue, and build-your-own options.
Advanced peptide protocols for recovery, healing, and optimization. BPC-157, TB-4, GLOW, GHK-Cu, growth hormone blends, and more.
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High-dose NAD+ via IV or injection for cellular energy, brain function, and recovery.
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Photobiomodulation for muscle recovery, skin health, and cellular regeneration.
Your own concentrated platelets injected to support tissue repair for joint pain and tendon issues.
Comprehensive program combining multiple therapies for full cellular energy restoration.
Important: Peptides are classified for research purposes only and are not FDA-approved to diagnose, treat, cure, or prevent any disease. Individual results vary based on health status, dosage, and consistency. Do not adjust your protocol without consulting your provider.
Questions? We're here.
Whether you want to adjust your protocol or explore additional therapies, our team can help.
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